摘要目的 研究沙美特罗/丙酸氟替卡松(舒利迭)对稳定期慢性阻塞性肺疾病(COPD)患者肺功能的影响及急性加重的次数.方法 42例COPD患者随机分为试验组(20例)和对照组(22例).两组均予常规治疗,试验组加用舒利迭(沙美特罗/丙酸氟替卡松,50μg/500μg)吸入,共随访观察疗程1年.两组均于治疗前后测定肺功能.结果 随访治疗1年,试验组肺功能较治疗前有显著改善,急性加重次数明显减少(P＜0.05);治疗组肺功能较治疗前改善不明显(P＞0.05).结论 联合应用舒利迭(沙美特罗/丙酸氟替卡松)治疗对稳定期慢性阻塞性肺疾病(COPD)患者肺功能有明显的改善作用,且急性加重的次数明显减少.

abstractsObjective To observe the effects of inhaled salmeterol/fluticasone propionate (Seretide)on lung function of the patients with stable chronic obstructive pulmonary disease (COPD)and the times for acute exacerbation.Methods 42 patients with COPD were randomly divided into two group,the experimental group (20cases) and control group (22cases).Two groups were to routine treatment.The experimental group was given seretide(salmeterol/fluticasone propionate ,50μg/500μg).Follow-up observation of treatment one year.All patients were examined in lung function before treatment and after therapy.Results After one year therapy,there was improvement of lung function and the times for acute exacerbation was reduce in experimental group (P ＜0.05).The control group' s lung function wasn' t improved compared with that before treatnent (P ＞ 0.05).Conclusion Compared with using seretide (salmeterol/fluticasone propionate,50ug/500ug)can improve pulmonary function and reduce the number of acute exacerbation.