摘要目的 探讨地尔硫卓对难治性不稳定型心绞痛的疗效和安全性.方法 42例对常规抗心绞痛治疗无效的不稳定型心绞痛患者,给予静脉持续泵入地尔硫卓72 h治疗.严格控制地尔硫卓的剂量.观察治疗前后心绞痛发作次数、发作时ST段压低及血流动力学指标的变化,并注意药物不良反应.结果 静脉滴注地尔硫卓治疗后,心绞痛得到有效控制,总有效率90.5%.与治疗前比较,治疗后的平均心绞痛发作次数减少、每次发作持续时间缩短、发作时ST段压低程度减轻(P＜0.05);治疗后血压、心率(P＜0.05)和收缩压×心率均明显降低(P＜0.01),未发现严重不良反应.结论 地尔硫卓静脉泵入治疗难治性不稳定型心绞痛安全、有效,但需严格控制药物剂量.

abstractsObjective To investigate the efficacy and safety of diltiazem to refractory unstable angina pectoris.Methods 42 unstable angina patients,who were failed to conventional anti-angina pectoris treatment,were treated with continuous infusion of intravenous diltiazem for 72 hours.Gradual titration of diltiazem was controlled.Angina attack frequency,ST segment depression and changes in blood rheologic indexes were observed before and after treatment.Results The attack of angina was effectively controlled after diltiazem treatment.The total effective rate was 90.1%.The average attack frequency,average attack duration and depression of ST segment were significantly decreased after diltizaem treatment(P ＜ 0.05).The blood pressure,heart rate ( P ＜ 0.05) and the systolic blood pressure × heart rate significantly decreased(P ＜ 0.01) after diltizaem treatment,without serious adverse reactions.Conclusion It was effective and safe to treat refractory unstable angina pectoris with diltizaem intravenous injection,but the dose titration should be strictly controlled.