摘要目的 探讨急性一氧化碳(CO)中毒患者血浆同型半胱氨酸(Hcy)浓度与血清肿瘤坏死因子-α(TNF-α)水平与病情严重程度和对预后的关系.方法 将82例急性CO中毒患者分为三组:A组轻度组、B组中度组和C组重度组,应用ELISA法对82例急性CO中毒患者的血浆Hcy浓度与血清TNFα水平进行检测.结果 重度组与中度组Hcy与TNF-α水平均明显高于轻度中毒组(P＜0.01),且重度组明显高于中度组(P＜0.05);迟发性脑病患者均发生在重度组,其Hcy与TNF-α水平与其他组的比较差异有显著性(P＜0.05).结论 检测急性CO中毒患者的血浆Hcy浓度与血清TNF-α水平,有助于评估急性期脑组织受损的严重程度及预测迟发性脑病的发生.

abstractsObjective To observe plasm homocysteine(Hcy)concentration and the serum levels of tumor necrosis factor-o(TNF-α) in patients and explore their relationship with the severe degree of acute carbonmonoxide poisoning and the prognostic value of the plasma homocysteine concentration and the serum levels of tumor necrosis factor-o.Methods 82 patients with acute carbon monoxide poisoning were divided into three groups:group A( gentleness poisoning group),group B(moderate poisoning group)and group C(severe poisoning group).The levels of Hcy and TNF-α of 82 patients were detected respectively with Enzyine-linked immunosobent assay ELISA.Results The level of Hcy and TNF-α in group B and group C were significantly higher than that in the control group A(P＜0.05),Hcy and TNF-α level in group C was obviously higher than in group B also( P＜0.05).There was statistically significant difference in the levels of Hcy and TNF-o between the patients with delayed encephalopathy which all occurred in group C and those in other groups( P＜0.05).Conclusion Determination of Hcy and TNF-α level can contribute to assessing the severe degree of acute carbonmonoxide poisoning and it can also predict the occurrence of delayed encephalopathy.