摘要目的 探讨缬沙坦和氨氯地平对高血压病患者血浆Apelin-12浓度的影响、两者的对比及其临床意义.方法 轻、中度高血压病患者组110例,随机分为缬沙坦治疗组58例,氨氯地平治疗组52例,治疗16周,酶联免疫法测定治疗前后血浆Apelin-12浓度,健康体检者50例作为对照.结果 高血压患者血浆Apelin-12降低与正常人比较,差异有统计学意义,缬沙坦治疗后血浆Apelin-12浓度升高程度高于氨氯地平组.结论 缬沙坦降压较氨氯地平更能升高血浆Apelin-12水平.

abstractsObjective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine.