摘要目的 研究多西紫杉醇(TXT)联合顺铂(DDP)方案二线治疗进展期胃癌的疗效和毒副作用.方法 既往应用FOLFOX4或XELOX方案化疗进展的晚期胃癌患者36例,采用多西紫杉醇(艾素)35 mg/m2,第1、8天,静滴;顺铂20 mg/m2,第1～5天,静滴,21 d为1个周期.结果 36例患者中,CR 0例,PR 10例,SD 12例,PD 14例,客观有效率(CR+PR)27.8%,中位生存期6.5个月,中位肿瘤进展时间4.4个月.毒副作用主要为中性粒细胞减少.结论 多西紫杉醇联合顺铂方案二线治疗进展期胃癌有效率较高,有生存优势,毒副作用可耐受.

abstractsObjective To evaluate the efficacy and toxicity of docetaxel(TXT) plus cisplatin(DDP) for patients with metastatic or recurrent advanced gastric cancer(AGC), previously treated with FOLFOX4 or XELOX regimen. Methods Twenty-seyen patients were treated with docetaxel (35 mg/m2 on day 1 and 8)and cisplatin (20 mg/m2 on days 1 to 5) every 3 weeks. Results Of the 36 patients qualified for efficacy analysis,the overall response rate was 27. 8% , including 10 cases of PR, 12 cases of SD and 14 cases of PD respectively. The median time to progression was 4. 4 months and median survival time was 6. 5 months. The predominant toxicity was hematologic, with neutrop enia. Non-hematological toxicity was rarely severe. Conclusion Combination chemotherapy with TXT/DDP given on 2 out of 3 weeks is well tolerated and active in heavily pretreated patients with AGC, even after prior exposure to OXA and 5-FU.