摘要目的 观察培美曲塞治疗老年晚期非小细胞肺癌的疗效和毒副反应,探寻相对应的护理方法.方法 通过对32例老年晚期非小细胞肺癌患者静滴培美曲塞,观察其疗效、毒副反应,并实施相应护理措施.结果 32例晚期非小细胞肺癌患者应用培美曲塞治疗,完全缓解(CR)2例,部分缓解(PR)17例,稳定(SD)6例,进展(PD)7例.发生的毒副反应主要有骨髓抑制、消化道反应、过敏反应及药物外渗等.其中2例Ⅱ度骨髓抑制,1例Ⅳ度骨髓抑制;Ⅱ度恶心呕吐19例,5例轻度便秘;2例出现严重皮肤瘙痒.经采取有效的对症治疗及积极的护理措施后都得到了缓解.结论 培美曲塞治疗晚期非小细胞肺癌患者,掌握正确的给药方法,及时进行毒副反应的处理和护理干预,能有效地提高患者生活质量.

abstractsObjective To observe the pemetrexed treatment of advanced non-small cell lung cancer and toxicity, corresponding to explore nursing. Methods 32 cases of elderly patients with advanced non-small cell lung cancer patients were infused pemetrexed in order to evaluate efficacy, toxicity, and implement appropriate care measures. Results 32 patients with advanced non-small cell lung cancer patients with pemetrexed treatment, complete remission (CR) 2 patients and partial remission (PR) 17 cases, stable (SD) 6 cases and progress (PD)7 cases. Toxicity occurs mainly in bone marrow suppression, gastrointestinal reactions, allergic reactions and drug extravasation and so on. 2 cases Ⅱ myelosuppression, 1 Ⅳ myelosuppression; Ⅱ nausea and vomiting in 19 cases, 5 cases of mild constipation; 2 patients had severe skin itching. The effective symptomatic treatment and active care measures have been eased. Conclusion Pemetrexed treatment of advanced non-small cell lung cancer patients, master the correct method of administration, toxicity of timely symptomatic treatment and care interventions can improve the quality of life of patients.