摘要目的 探究转录因子21(TCF 21)在乳腺肿瘤中的表达及临床意义.方法 收集2006年1月至2008年1月解放军沈阳军区总医院手术切除的78例乳腺肿瘤石蜡包埋组织块标本,并采用免疫组化法检测78例乳腺肿瘤组织中TCF 21的表达情况.结果 TCF 21总表达缺失率为51.28%,TCF 21蛋白表达缺失率与乳腺肿瘤的大小、淋巴结转移及5年生存期相关(P<0.05);与患者年龄、TNM分期、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)的状况无关(P>0.05).结论 检测TCF 21在乳腺癌患者中的表达缺失情况有助于乳腺肿瘤预后的判断.

abstractsObjective To explore the expression and significance of transcription factor 21 ( TCF 21)in breast carcinoma. Methods A retrospective study was performed on 78 cases of paraffin embedding tissues collected from breast carcinoma since January 2006 to January 2008 in The General Hospital of She-nyang Military Command. The expression of TCF 21 in 78 cases of breast carcinoma was detected by immu-nohistochemical staining method. Results TCF 21 total expression deletion rate was 51. 28%, TCF 21 protein expression deletion rate were associated with breast carcinoma tumor size, lymph node metastasis and five-year survival(P<0. 05), while not associated with the patient age, TNM staging and estrogen re-ceptor(ER), progesterone receptor(PR)and human epidermal growth factor receptor 2(HER2)status(P>0. 05). Conclusion Detection of TCF 21 in breast carcinoma might contribute to the prognosis evaluation.