摘要目的 回顾性分析化学治疗联合肠内营养治疗对食管癌、贲门癌营养不良患者的疗效及安全性.方法 收集2014年12月至2016年4月解放军沈阳军区总医院收治的首次接受化学治疗的60例晚期食管癌、贲门癌营养不良患者的临床资料,分为联合治疗组(32例)和单纯化学治疗组(28例).单纯化学治疗组采用化学治疗,联合治疗组在此基础上联合肠内营养治疗.观察比较两组患者治疗前后的体质量、白蛋白、前白蛋白、血红蛋白,以及并发症(腹胀、腹泻、恶心呕吐)等发生情况.结果 联合治疗组在营养支持治疗后与单纯化学治疗组比较,体质量、白蛋白、前白蛋白、血红蛋白明显升高,差异有统计学意义(P<0.01),Ⅱ级以上的消化道不良反应明显较少,差异有统计学意义(P<0.05).结论 化学治疗联合肠内营养治疗能有效改善食管癌 、贲门癌患者的机体营养状况,提高免疫力,减少因化学治疗引起的胃肠道不良反应,提高患者对抗癌治疗的耐受性,值得临床推广.

abstractsObjective To investigate the curative effect,safety and feasibility of enteral nutrition for improving nutritional condition of esophageal and cardiac carcinoma patients undergoing chemotherapy. Methods A retrospective study was performed on 60 malnutrition patients with esophageal and cardiac carcinoma who were admitted from December 2014 to April 2016. Patients were divided into the treatment group(n=32)and the control group(n=28). Patients in the treatment group received chemotherapy,the others in the control group received chemotherapy combined with enteral nutrition. The weight,albumin,pre-albumin,hemoglobin and complications(abdominal distention,diarrhea,nausea and vomiting) were moni-tored before and after chemotherapy,respectively. Results The weight,albumin,prealbumin and hemoglo-bin in the treatment group were significantly higher than those in the control group(P<0. 01),complica-tions were significantly reduced(P<0. 01). Conclusion Early postoperative enteral nutrition therapy can improve the nutritional status and immunity. It also can reduce the gastrointestinal adverse reaction caused by chemotherapy and improve patient tolerance of anti-cancer treatment,and it is worthy of clinical promotion.