摘要目的 探讨不同神经功能缺损程度脑梗死患者血尿酸(SUA)水平变化及其与短期预后关系. 方法 选取2014年2月至2016年12月滨州市中心医院神经内科收治的不同神经功能缺损程度的脑梗死患者112例,根据美国国立卫生研究院卒中量表(NIHSS)分为两组,轻度组51例,中重度组61例. 发病后第1、7天,分别统计NIHSS评分,并测定SUA水平,第1、3个月分别通过为改良RANKIN量表(mRS)对患者预后进行评估. 结果 中重度组SUAday7水平显著低于SUAday1水平,且中重度组SUA差值显著高于轻度组,差异有统计学意义(P<0.05);轻度组患者发病后第1、3个月末均预后良好;中重度组患者发病后第1个月31例患者预后不良,第3个月20例患者预后不良. 经logistic回归分析可知,ΔSUA、NIHSSday1均为脑梗死发病后第1个月末预后不良的危险因素(P<0.05),NIHSSday1为脑梗死发病后第3个月末预后不良的危险因素(P<0.05). 结论 脑梗死发病第1天内NIHSS评分为预后不良的危险因素,而SUA降低值与短期预后有关.

abstractsObjective To investigate the changes of serum uric acid (SUA)and its relationship with short-term prognosis in patients with cerebral infarction due to different neurological deficits. Methods Aretrospective study was performed on 112 cases of patients with cerebral infarction due to dif-ferent neurological deficits who were admitted from February 2014 to December 2016.According to the Na-tional Institutes of Health Stroke Scale (NIHSS),patients were divided into the mild-moderate group(n=51)and the moderate-severe group (n=61).The NIHSS score was statistically analyzed after the 1st and 7th day onset of disease,respectively,the SUA level was determined,and the prognosis of the patients was assessed by the improved RANKIN scale(mRS)at the 1st and 3rd month.Results In the moderate-severe group,level of SUAday7was significantly lower than that of SUAday1,the difference value of SUA in the mod-erate-severe group was significantly higher than that in the mild-moderate group,and the difference had sta-tistical significance (P <0.05);the prognosis in the mild-moderate group was good at the 1st and 3rd month after onset,while in the moderate-severe group,31 patients had poor prognosis at the end of the first month,20 patients had poor prognosis at the end of the third month.The logistic regression analysis showed that ΔSUA and NIHSSday1were the risk factors of prognosis at the end of the first posterior cerebral infarc-tion (P<0.05),NIHSSday1was a risk factor for prognosis at the end of 3rd month after cerebral infarction (P<0.05).Conclusion The NIHSS score is the risk factor of prognosis in the first day of cerebral infarc-tion,while the reduction of SUA is related to the short-term prognosis.