检索历史 清除

目的 探讨舍尼亭联合宁泌泰治疗前列腺电切术后膀胱过度活动症( OAB)的有效性和安全性.方法 选取2015年1月至2017年12月孝义市人民医院泌尿外科收治的68例经尿道前列腺电切术后OAB患者,采用随机数表法随机分为联合治疗组和单药治疗组,每组34例,单药治疗组患者口服舍尼亭,联合治疗组在单药治疗组的基础上口服宁泌泰.比较两组患者治疗前后膀胱过度活动症评分(OABSS)、患者膀胱状况感知量表( PPBC)及膀胱过度活动症健康相关生活质量量表(OAB-q)的变化,同时比较两组患者的临床治疗效果和不良反应.结果 治疗后,联合治疗组OABSS评分[(4.2 ± 1.1)分]、PPBC评分[(2.3 ± 0.8)分]、OAB-q评分[(43.5 ± 8.4)分]、不良反应发生率(5.8% )均低于单药治疗组[(7.3 ± 1.9)分、(4.6 ± 1.2)分、(76.4 ± 11.5)分、(23.2% )],联合治疗组有效率(94.1%)高于单药治疗组(82.4%),差异有统计学意义(P<0.05).结论 舍尼亭联合宁泌泰治疗前列腺电切术后OAB能明显减轻患者症状、提高临床治疗效果、改善患者生活质量,且药物不良反应少,使用安全可靠.

Objective To investigate the efficacy and safety of tolterodine tartrate combined with Ningbitai in the treatment of overactive bladder ( OAB ) after transurethral resection of the prostate. Methods A retrospective study was performed on 68 cases of OAB patients who underwent transurethral resection of the prostate from January 2015 to December 2017.Patients were randomly divided into the com-bined treatment group and single drug treatment group,with 34 cases in each group.Patients of the single drug treatment group were treated with tolterodine tartrate,the others in the combined treatment group were given oral Ningmitai on the basis of single drug treatment group.The changes of bladder hyperactivity score (OABSS),bladder status perception scale (PPBC) and health-related quality of life scale ( OAB-q) of pa-tients in the two groups before and after treatment were compared,and the clinical treatment effect and ad-verse reactions of the two groups were compared. Results After treatment,OABSS score (4.2 ± 1.1),PP-BC score (2.3 ±0.8),OAB-q score (43.5 ±8.4),and the incidence of adverse reactions (5.8%)in the combined treatment group were lower than those in those in the single drug treatment group [(7.3 ± 1.9), (4.6 ±1.2),(76.4 ±11.5)and 23.2%],the effective rate in the combined treatment group (94.1%) was higher than that in the single drug treatment group (82.4% ),(P<0.05). Conclusion Tolterodine tartrate combined with Ningmitai in the treatment of OAB after transurethral resection of the prostate can significantly reduce the symptoms of patients,improve the clinical efficacy and the quality of life of patients, and has less adverse drug reactions,which is safe and reliable.