摘要在罗马Ⅳ诊断体系中，与慢性便秘相关的疾病包括功能性便秘、阿片引起的便秘、便秘型肠易激综合征和功能性排便障碍4种疾病，每种疾病有其临床表现特点和相应的病理生理机制。罗马Ⅳ对其诊断标准的修订和完善主要基于近年的研究进展，并强调对便秘相关的功能性疾病的诊断要尽量少地、有针对性地选择辅助检查（包括结肠镜和病理生理学检查）。充分理解每种疾病的临床表现特点和病理生理机制，对灵活应用罗马Ⅳ诊断标准、提高诊断的准确性和指导治疗均具有十分重要的意义。

abstractsIn Rome Ⅳ diagnostic system, disorders associated with chronic constipation include functional constipation, opioid-induced constipation, irritable bowel syndrome with predominant constipation and functional defecation disorders, each disorder has the relative characteristics of clinical manifestations and underlying pathophysiology. RomeⅣ committee modified the diagnostic criteria based on current research achievements , and recommended to make the diagnosis of functional constipation disorders with minimal laboratory test and with indications for colonoscopy and pathophysiological tests. Understanding the clinical manifestations and pathophysiology of functional constipation disorders are helpful for clinicians to apply the Rome diagnostic criteria and improve the accuracy of diagnosis and treatment for the patients with chronic constipation.