肠菌移植治疗炎症性肠病专家共识(2025版)
Consensus of Chinese experts on gut microbiota and fecal microbiota transplantation in inflammatory bowel disease (2025 edition)
摘要近年来,肠菌移植(FMT)治疗炎症性肠病(IBD)的临床及基础研究取得了诸多进展。在新的微生态诊疗理念不断应用于临床的情况下,规范FMT治疗IBD的流程,为广大临床工作者提供基于最新循证医学证据的共识意见,很有必要。由中华医学会肠外肠内营养学分会、中国人体健康科技促进会肠道微生态与肠菌移植专业委员会和上海市预防医学会肠道微生态专业委员会牵头组织,参考国外最新共识和国际国内相关研究进展,汇集国内专家临床实践经验,编撰制定了《肠菌移植治疗炎症性肠病专家共识(2025版)》。本共识围绕FMT适应证选择、肠道菌群检测、IBD移植的供体选择与质量控制、移植期注意事项、FMT的移植途径与剂量的选择、FMT并发症的处理以及未来研究方向等问题共整理出29条推荐意见,旨在为FMT治疗IBD提供规范化实践指导。
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abstractsIn recent years, significant progress has been made in the clinical and basic research on fecal microbiota transplantation (FMT) for the treatment of inflammatory bowel disease (IBD). With the continuous application of new microbiota-based diagnostic and therapeutic concepts in clinical practice, it is imperative to standardize the diagnostic and therapeutic processes of FMT for IBD and provide consensus recommendations based on the latest evidence from evidence-based medicine for clinical practitioners. Organized by the Chinese Society for Parenteral and Enteral Nutrition of the Chinese Medical Association, the Gut Microbiota and FMT Committee of the Chinese Society for Human Health Sciences, and the Gut Microbiota Committee of the Shanghai Preventive Medicine Association, and with reference to the latest international consensus and relevant research advancements, this consensus integrates the clinical practice experience of domestic experts to establish the "Consensus of Chinese experts on gut microbiota and fecal microbiota transplantation in inflammatory bowel disease (2025 edition)". This consensus provides 29 recommendations focusing on the selection of FMT indications, gut microbiota analysis, donor selection and quality control for IBD transplantation, considerations during the transplantation period, selection of transplantation routes and dosages, management of FMT-related complications, and future research directions, aiming to offer standardized guidance for the clinical application of FMT in the treatment of IBD.
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