缓解-复发型多发性硬化与化脓性脑膜炎患者血脑屏障损害及slCAM-1、TN F-a水平的临床分析

Clinical analysis of damaged blood-brain barrier and sICAM-1, TNF-a in relapsing relmtting form of multiple sclerosis and bacterial meningitis

二维码有效期 120s

摘要目的探讨可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,slCAM-1)、肿瘤坏死因子-a(tumor necrosis factor-a,TNF-a)及血脑屏障(blood-brain barrier,BBB)损害在复发-缓解型多发性硬化(relapsing remitting form of multiple sclerosis,RRMS)和细菌性脑膜炎(bacterial meningitis,BM)发生中的作用.方法应用酶联免疫吸附试验(enzyme-linked immunosorbent assa,ELISA)法对24例KKMS、12例非炎性神经系统疾病(non-inflammatory neurological disease,NIND)、8例BM患者血清及脑脊液中slCAM-1、TNF-a含量进行检测,并计算白蛋白比值(albumin quotient,QA)以评估BBB功能状态.结果 ①RRMS组QA异常者占67%,BM组则为100%.②与NIND组相比,RRMS组与BM组血清和脑脊液中的slCAM-1水平显著升高,RRMS组BBB异常者脑脊液中slCAM-1水平较NIND组显著升高,而BBB正常者差异则无显著性.③与NIND组相比,RRMS组血清TNF-a水平未见变化,脑脊液中TNF-a检测阳性率低,差异无显著性,而BM组血清及脑脊液中TNF-a水平显著升高.结论 BBB损害及ICAM-1参与了多发性硬化与化脓性脑膜炎的免疫病理机制.