摘要Objective To evaluate the effects of Zhibitai (ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group (n =44,treated with ZBT 0.48 g twice per day)and the atorvastatin (ATO) group (n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol (TC),triglyceride (TG),high and low density lipoprotein cholesterol (HDL-C and LDL-C) and pulse wave velocity (PWV) were investigated before and eight weeks after treatment.Results The serum levels of TG,TC,LDL-C,femoral-ankle PWV (FAPWV) and carotid-radial PWV (CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks (P ＜0.05).There was no significant alteration in HDL-C and carotid-femoral PWV (CFPWV) levels in both ZBT and ATO groups (P ＞0.05) after eight-week's treatment.Conclusion ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering effect.The efficacy of ZBT is similar to that of ATO.