摘要[ Objective] The study was aimed to assess the state of antigen-presenting cells (APC) and humoral immunity in the female genital tract during the HPV- infection. [Method] This study was conducted at the sample of 30 females with verified HPV-infection.30 healthy females were examined as a control.The functional state of APC was determined immunohystochemically by the frequency of the positive reaction to the major histocompatibility complex (MHC)-CⅡ,CDla and langerine in the samples of cervical tissue.The following monoclonal antibodies were used:anti-DR (Dako),anti-CDla (Dako) and anti-Langerine (LIR,Dardilly).The obtained data were analyzed statistically with performing Mann-Whitney test for independent samples.The data were analyzed using the software Statistica 7.0 (StatSoft Inc.,USA) for Windows. [Result] There was determined that the patients with the genital HPV-infection had the moderate deficiency of sIgA,IgA and IgG whereas IgM activity wasn't changed.They were also experienced the decrease of CDla+ cells population as well as NHC-CⅡ and Langerine+ DC in the cervical epithelium.[ Conclusion ]There is discussed the expedience to include the assessment of the functional state of APC of the patients with the HPV-infection into the national chnical protocols.