摘要维生素D具有调节钙磷代谢及维持骨骼健康的作用，近年来越来越多的研究表明维生素D及其受体具有保护糖尿病肾病(DN)的潜力。动物研究和临床试验均显示维生素D水平与DN风险之间的相关性，补充维生素D或其活性衍生物可改善内皮细胞损伤，减少炎症反应、减少蛋白尿，减轻肾纤维化并因此延缓DN进程。因此维生素D及其受体有望成为DN预防及治疗的新选择。本文综述维生素D对DN保护机制的研究新进展。

abstractsVitamin D can regulate calcium and phosphorus metabolism and maintain bone health. In recent years, more and more studies have shown that vitamin D and its receptors have the potential to protect diabetic nephropathy. Animal studies and clinical trials have shown the correlation between vitamin D levels and the risk of diabetic nephropathy. Supplementation of vitamin D or its analogs can improve endothelial cell damage, reduce inflammation, proteinuria, and renal fibrosis and thus delay the process of diabetic nephropathy. Therefore, vitamin D and its receptor are expected to become a new choice for the prevention and treatment of diabetic nephropathy. This review summarizes the new research progress of vitamin D on the protective mechanism of diabetic nephropathy.