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目的 探讨血清同型半胱氨酸(Hcy)对于结肠癌的诊断价值.方法 以北京天坛医院2011年3月至2016年6月收集的结肠癌患者50例(结肠癌组)以及健康人50名(对照组)为研究对象,采用速率法检测其血清Hcy浓度.采用两独立样本t检验分析两组Hcy浓度之间的差异,并使用 ROC曲线评价Hcy对结肠癌的诊断价值.结果 结肠癌组的血清Hcy浓度为(18.6±8.9) μmol/L,健康对照组的血清Hcy浓度为(10.7±4.3) μmol/L,结肠癌组血清Hcy浓度明显高于健康对照组,差异有统计学意义(t=5.627,P<0.01).血清Hcy 的ROC曲线的曲线下面积为AUC=0.775,cut-off值为18.5 μmol/L.敏感度为0.50,特异度0.94.渐进95%置信区间为0.682~0.868(P<0.01).结论 血清Hcy可以作为结肠癌诊断的参考指标之一.

Objective To investigate the diagnostic value of serum homocysteine in the diagnosis of colon cancer.Methods The performance rate method was used to detect the level of serum homocysteine(Hcy) in colon cancer group(50 cases) who were treated in Beijing Tiantan Hospital Affiliated to Capital Medical University from March 2011 to June 2016 and control group(50 cases).The expression of independent samples t test was used to analysis of the difference of the Hcy levels between the two groups.The ROC curve was used to evaluate the value of Hcy in diagnosis of colon cancer.Results The serum Hcy level in colon cancer group was (18.6±8.9) μmol/L,in healthy control group was (10.7±4.3) μmol/L,colon cancer group serum Hcy levels were significantly higher than those of healthy control group,there was significant difference(t=5.627,P<0.01).AUC of ROC curve was 0.775,cut-off value of 18.5 μmol/L,sensitivity was 0.50,specificity was 0.94,95%CI was 0.682-0.868(P<0.01).Conclusion Serum Hcy can be used as a reference index of the diagnosis of colon cancer.