Experimental model of renovascular hypertension

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摘要Objective To establish a model of renovascular hypertension.Methods A 4/0 resorbable chromic catgut ligature was used to ligate subtotally the renal arteries of 18 dogs, forming experimental renovascular hypertension steadily. Blood pressure, plasma renin activity, the ultrastructural changes of juxtaglomerular apparatus and renal artery wall were studied after the constriction.Results It was reasonable that renal blood flow measured with an electromagnetic flowmeter was reduced by 30% after the constriction. The pathological changes of the induced renal artery stenosis were similar to those of fibromuscular dysphasia. Conclusion The findings provide valuable evidence for the treatment of renovascular hypertension.

作者单位 Department of Radiology, Tianjin Medical University Hospital, Tianjin 300052, China ^[1] Electronscopic Center, Tianjin Medical University, Tianjin 300052, China ^[2] Department of Tumour Immunology, Tianjin Institute of Urological Surgery, Tianjin 300211, China ^[3]

分类号 R5

发布时间 2006-01-12

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