摘要目的　了解血浆载脂蛋白A-Ⅳ（apoA-Ⅳ）水平与冠脉粥样硬化及其他危险因素的关系。方法　用ELISA测定181例接受冠脉造影（CAG）患者的血浆apoA-Ⅳ水平。根据冠脉情况将患者分为冠心病（CHD）组（CAG有狭窄病变，n=118）和对照组（CAG正常，n=63）。计算不同病变的狭窄积分以评价粥样硬化的严重程度。同时测定apoA-I、apoB、Lp(a)、HDL-C、LDL-C、TG和TC。单因素分析和logistic回归分析明确冠脉粥样硬化与血浆apoA-Ⅳ水平的关系。结果　CHD组血浆apoA-Ⅳ水平低于对照组，血浆apoA-Ⅳ水平与冠脉粥样硬化严重程度呈弱的负相关。apoA-Ⅳ是CHD的相对独立危险因素。我们还发现apoA-Ⅳ与TG水平呈正相关。结论　apoA-Ⅳ可能对于预测CHD和冠脉粥样硬化严重程度非常重要，它还可能在甘油三酯代谢中起着重要作用。

abstractsObjective　To evaluate the relationship between plasma apoA-Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors.Methods　Using ELISA techniques, plasma apoA-Ⅳ levels were quantified in 181 patients who underwent coronary angiography (CAG). Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n=118