摘要目的　进一步揭示海洛因滥用对机体的严重危害和阐明由一氧化氮等自由基引起、过氧化和脂质过氧化对海洛因滥用者的严重损伤。方法　检测了114例海洛因滥用者（HAs）和100例健康志愿者（HVs）的血浆一氧化氮（P-NO）含量、血浆过氧化脂质（P-LPO）含量及红细胞超氧化物歧化酶（E-SOD）活性、红细胞过氧化氢酶（E-CAT）活性、红细胞谷胱甘肽过氧化物酶（E-GSH-Px）活性和红细胞过氧化脂质（E-LPO）含量并作比较，用直线回归和相关、逐步回归和相关分析了HAs的上述检测值与海洛因滥用史（HAT）和每日海洛因滥用量（DHAQ）之间的关系。结果　与HAs组的上述平均值相比较，HAS组的P-NO、P-LPO、E-LOP平均值均显著升高（P<0.0001），而P-VC、P-VE、P-β-CAR、E-SOD、E-CAT、E-GSH-Px平均值均显著降低（P<0.0001）；直线回归和相关分析表明，随着HAs的HAT延长和DHAQ增加，HAs的P-NO、P-LPO、E-LPO值逐渐升高（P<0.001），而P-VC、P-VE、P-β-CAR、E-SOD、E-CAT、E-GSH-Px值逐渐降低（P<0.001）；逐步回归和相关分析表明，HAs的HAT、DHAQ与P-NO、P-VC、P-VE值相关最密切。结论　HAs体内的氧化抗氧化平衡严重失调，由一氧化氧等自由基引起的氧化、过氧化和脂质过氧化损伤严重加剧，在戒毒中必须给予HAs充分的维生素C、维生素E和β-胡萝卜素等抗氧化剂，以减缓对机体的损伤。

abstractsObjective　To further reveal serious risks of heroin abuse to human body and clarify grave injuries of oxidation, peroxidation and lipoperoxidation induced by nitric oxide and other free radicals to heroin abusers.Methods　Determined and compared plasma levels of nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE), β-carotene (P-β-CAR), lipoperoxides (P-LPO) and erythrocyte activities of superoxide dismutase (E-SOD), catalase (E-CAT), glutathione peroxidase (E-GSH-Px) and erythrocyte level of lipoperoxides (E-LPO) in 137 cases of heroin abusers (HAs) and 100 cases of healthy volunteers (HVs), used linear regression and correlation, stepwise regression and correlation to analyze correlation among heroin-abusing-duration (HAD), daily-heroin-abusing-quantity (DHAQ) with above determination values in the HAs.Results　Compared with the above average values in the HVs group, the average values of P-NO, P-LPO, E-LPO in the HAs group were significantly increased (P<0.0001), the average values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GSH-Px were significantly decreased (P<0.0001); the analysis of linear regression and correlation showed that with ascending of the HAD and DHAQ in the HAs, the values of P-NO, P-LPO, E-LPO were gradually increased (P<0.0001), the values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT, E-GSH-Px were gradually decreased (P<0.0001); the analysis of stepwise regression and correlation suggested that the correlation among the HAD, DHAQ with the values of P-NO, P-VC, P-VE was the closest. Conclusion　The balance between oxidation and antioxidation in the HAs was seriously destroyed, and the injuries induced by nitric oxide and other free radicals, oxidation, peroxidation and lipoperoxidation reactions to the body of HAs gravely exacerbated. In the abstaining from heroin dependence, therefore, it should consider that sufficient quantum antioxidants such as VC, VE and β-CAR are dosed to the HAs so as to abate the injuries to their bodies.