摘要目的回顾性评价稻栖黄单胞菌(Flavimonas oryzihabitans)感染的临床特点和细胞免疫功能。方法我们鉴定了我院自1994年11月至1998年12月稻栖黄单胞菌感染11例，收集的相关资料包括稻 栖黄单胞菌感染的临床表现、潜在的疾病及统计资料等，测定了11株稻栖黄单胞菌对15种抗菌素的体外 药敏试验，利用流式细胞仪测定了外周血T细胞亚群(CD3、CD4、CD8细胞数和CD4/CD8比值)和NK (CD16+56)细胞数。 结果本组稻栖黄单胞菌感染中男性6例，女性5例，平均年龄47.64岁(5-69岁)。除一例外所有病人 有严重的潜在疾病，9(81.8％)例病人为医院内感染，2(18.2％)例病人为院外感染(病例2和5)；8 (72.7％)例表现为原发性稻栖黄单胞菌血症，胸膜炎、软组织感染和腹膜炎各一例；所有菌株对丁胺卡那 霉素、庆大霉素及环丙沙星敏感，而对头胞唑啉、呋喃坦啶和青霉素不敏感；CD3、CD4、CD4/CD8和NK细 胞值低于正常(P＜0.01)；抗菌素治疗后体温≤37℃平均为3.5天(1-6天)，所有病人临床症状均消失和 治愈。 结论稻栖黄单胞菌感染是临床上非常少见的病例，与潜在疾病和外来材料存在有关；免疫功能异常是引 起稻栖黄单胞菌感染的主要因素之一

abstractsObjective To assess retrospectively the clinical characteristicsand cell immune function of infections caused by Flavimonas oryzihabitans (F. oryzihabitans). Methods We indentified 11 cases of F. oryzihabitans positive cultures from all microbial cultures collected in our hospital from November 1994 to December 1998. Relevant clinical information was collected, including demographic data, underlying disease, and clinical manifestations of the F. oryzihabitans infections. Minimal inhibitory concentrations (MICs) of 15 antimicrobial agents against the 11 F. oryzihabitans isolates were determined. Cell immune function tests were determined by flow cytometry including T lymphocyte subsets (CD3, CD4, CD8 and ratio CD4/CD8) and NK cells (CD16+56) from peripheral blood. Results Six of these patients with infections caused by F. oryzihabitans were male, 5 were female and the mean age was 47.64 years (range, 5 to 69 years). All but 1 patients had severe underlying diseases. 9 (81.8%) of these patients developed infection while hospitalization and 2 (18.2%) before hospitalization (Cases 2 and 5). 8 (72.7%) of these patients manifested primary F. oryzihabitans bacteremia and one each (9.1%) had pleurisy, soft tissue infection and peritonitis. All these isolates were susceptible to amikacin, gentamicin and ciprofloxacin, but resistance to cefazolin, nitrofurantoin, penicillin and piperacillin. CD3, CD4, CD4/CD8 and CD16+56 value (x±s) of these patients were significatly lower than normal values (P<0.01). The mean time of body temperature fell =37 after antibiotic treatment in these patients was 3.5 days (range, 1 to 6 days). All clinical symptom caused F. oryzihabitans after antibiotic treatment disappeared and all patients recovered. Conclusions Infections caused by F. oryzihabitans was very few clinically, and relative to underlying diseases and the presence of foreign material. Immune function abnormality was among mostly factor for the F. oryzihabitans infections.