摘要目的探讨磁化支架对经皮经腔冠状埃及成形术(PTCA)后冠状动脉再狭窄的防治作用。方法 20只健康杂种犬，超大球囊反复扩张损伤靶血管（前降支或旋支中段）制备PTCA术后冠状动脉狭窄模型（>50%）,后随机分成对照组和实验组各10只。对照组靶血管置入普通Palmaz支架，实验组靶血管置入磁化Palmaz支架。手术前后不用抗血小板药和抗凝药，术后6个月冠状动脉造影，并处死犬切取靶血管3?cm进行组织病理学检查。结果冠状动脉造影冠状动脉再狭窄率对照组30%，实验组0；组织病理学检查靶血管平均内膜厚度（对照组2.98±0.56?mm), (实验组1.13±0.41?mm）有显著差异，P<0.05。结论磁化支架对犬PTCA术后冠状动脉再狭窄可能具有防治作用。

abstractsObjective　To investigate the effects of magnetic stents on coronary restenosis after percutaneous transluminal coronary angioplasty (PTCA). Methods　Twenty dogs were randomly divided into the control and experimental groups, each with 10 dogs. The control group was given common Palmaz-stents in the 6-8 segment of left anterior descending coronary artery or in the 11-14 segment of the left circumflexus. The experimental group was given magnetic stents in the same parts of the coronary arteries. The dogs were not given antiplatelet or anticoagulant drugs before or after the operation. Six months later, the 20 dogs were subjected to coronary angiographies, and then were sacrificed. Three centimeter long segments of the target vessels were cut for pathological examination. Results　The degree of restenosis in 3 dogs of the control group was more than 50%, but none in the experimental group experienced restenosis. The average thickness of the tunica intima of the target artery was 2.98±0.56?mm in the control and 1.13±0.41?mm in the experimental group (P<0.05). Conclusion　Magnetic stents could have a significant preventive effect on coronary restenosis.