摘要目的研究巨细胞病毒和动脉粥样硬化的关系.方法用PCR的方法检查了巨细胞病毒在颈内动脉、冠状动脉和血中的分布情况,并与健康人作了对照.结果 83.3%-86.7%的动脉粥样硬化病人的动脉壁中存在巨细胞病毒,而非动脉粥样硬化病人的动脉壁中只有6.7%的标本中见巨细胞病毒,两者相比有显差差异(P＜0.01);在42.4%的动脉粥样硬化病人的血中查见巨细胞病毒,而对照组中只有3%查见了巨细胞病毒,两者之间有显差性差异(P＜0.01).结论巨细胞病毒在动脉粥样硬化和动脉粥样硬化性脑梗塞的病理过程中起着重要的作用.

abstractsObjective To investigate the association of cylomegalovirus with atherosclerosis.Methods The presence of cylomegalovirus(CMV)nucleic acids was demonstrated in carotid and coronary arteries of patients with and without atherosclerosis by polymerase chain reaction(PCR).CMV was detected by PCR in the blood of patients with and without atherosclerosis.Results 83.3% - 86.7% of the samples obtained from atherosclerotic patient arterial walls were shown to contain viral nucleic acids(CMV),CMV could be found among 6.7% of patients' arterial wall without atherosclerosis,significant difference can be found between them(P ＜ 0.01).In blood CMV could be found in 42.4% of patients with atherosclerosis,in the control group,only 3% of samples had CMV,P＜0.01.Conclusion CMV plays an important role in the pathologic process of the atherosclerosis and the atherosclerotic cerebral infarction.