高频超声显像评价慢性压力负荷大鼠心肌结构和功能的动态变化
Serial high-frequency ultrasound assessment of progressive changes in left ventricular structure and function in rats with chronic pressure overload
目的通过对正常和升主动脉缩窄大鼠进行高频超声检测,评价高频超声显像对大鼠心脏结构和功能测定的可行性和准确性;动态探测升主动脉缩窄术后不同时间大鼠心脏结构和功能的改变 .方法雌性大鼠38只,正常组10只,实验组28只.实验组分为手术组(16只)和同期假手术组(12 只),动态测定术后12周、20周的超声变化.两维超声测定仪(美国ATL3000HD超声仪,探头7.5?mHz),取胸骨旁左室长轴和短轴切面.结果高频超声可清晰显示大鼠左室结构并可进行准确测量.与同期假手术组比较,术后12周手术组左室壁明显增厚,左室重量明显增加(P<0.01),但左室腔大小正常,FS%正常( P>0.05).术后20周左室壁仍增厚但无加重,左室重量进一步增加(P<0.01),左室腔轻度扩大,FS%下降(P<0.05).结论高频超声显像可成为判定大鼠心室结构和功能的一种无创的检测方法,对动态观察大鼠由心肌肥厚到心力衰竭转变中的心室重构建评价干预药物的疗效有重要价值.
更多Objective To determine the feasibility and accuracy of high-frequency ultrasound in evaluating the left ventricular (LV) structure and function in normal and pressure overload rats and to examine the changes of the left ventricle during its transition from hypertrophy to heart failure. Methods Thirty-eight female rats were randomly assigned to normal (n=10), operated (n=16) and sham-operated (n=12) groups. Parasternal long axis and short axis images were acquired by a 7.5mHz linear ultrasound probe at 12 weeks and 20 weeks after the operation respectively.Results Left ventricular structure and function could be satisfactorily imaged for dimensions and mass. Compared to the sham-operated groups, at 12 weeks after the operation, the operated rats had increased LV wall thickness and mass (P<0.01) with normal cavity and FS% (P>0.05). At 20 weeks after the operation, the LV wall thickness showed no further progressive change and the LV mass increased greatly with slightly dilated LV cavity and decreased FS% (P<0.05).Conclusions High-frequency echocardiography provides a useful means to noninvasively evaluate LV dimensions, mass and function in rats. It will have great value for evaluating LV remodeling during the transition from LV hypertrophy to heart failure, as well as the effects of intervening drugs.
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