近交系大鼠胰十二指肠移植门脉回流,腔脉回流而致胰岛素敏感比较
Insulin sensitivity after pancreaticoduodenal transplantation with systemic and portal venous drainage in inbred rats
目的评价近交系药物性糖尿病大鼠胰十二指肠移植门脉回流、腔脉回流而致外周胰岛素新陈代谢结果. 方法和结果 8例采用供体门静脉同受体肠系脉上静脉相吻合,移植前、后血胰岛素浓度、正常血糖-高胰岛素钳夹试验表明胰岛素敏感性无明显改变.然而,10例采用供体门静脉同受体腔静脉相吻合,移植后血胰岛素浓度明显升高,正常血糖-高胰岛素钳夹试验表明胰岛素敏感性明显下降. 结论胰腺移植门脉回流在外周胰岛素敏感性中起了决定作用.
更多Objective To assess the metabolic consequences of pancreatic transplantation with portal venous drainage and systemic venous drainage in induced inbred rats with streptozocin.Methods Pancreaticoduodenal transplantation was performed on 8 rats with the donor portal veins anastomosed to the recipient superior mesenteric vein and on 10 rats with the donor portal veins anastomosed to the recipient cava inferior vein. We measured the recipients' weight, urine and plasma glucose concentration, plasma insulin concentration at the beginning, and before and after transplantation. We used the euglycemi-hyperinsulinemic glucose clamp test and glucose infusion required as an index of insulin sensitivity.Results The plasma glucose and insulin concentration recovered to normal after transplantation in the portal venous drainage group. The plasma insulin levels increased in the systemic venous group after transplantation. There was a difference in the glucose infusion required between the two groups.Conclusion These data imply that portal venous drainage of the transplanted pancreas is an important factor in the determination of peripheral insulin sensitivity.
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