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日本血吸虫单克隆抗独特型抗体NP30诱导保护性免疫的研究

Protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum

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目的 观察日本血吸虫单克隆抗独特型抗体NP30主动免疫小鼠诱导的保护性免疫力.方法 选择L16(4×212)正交设计,8周龄昆明种小鼠随机分为16个实验组和2个对照组.对照组腹腔接种SP2/0腹水.所有小鼠在腹部皮肤感染100±2条日本血吸虫尾蚴,尾蚴攻击后第30天处死小鼠,行左心室-门静脉灌注收集成虫,计算减虫率.结果 根据不同的免疫方案,NP30主动免疫可产生22.36%-50.46%的减虫率,并确定了最优免疫方案.结论 提示NP30主动免疫对尾蚴攻击可产生一定的保护力,具有血吸虫疫苗候选分子的潜能.

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Objective To investigate the protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum in mice.Methods An orthogonal table L16(4×212) was selected as the experimental design. Eight-week-old Kunming outbred mice (male and female) were randomly divided into 16 experimental groups and 2 control groups. Control groups were injected with SP2/0 ascites intraperitoneally. Mice from each group were infected with 100±2 cercariae of Schistosoma japonicum in the abdominal skin and were sacrificed on the thirtieth day postchallenge. Adult worms were recovered and counted by perfusion of the left ventricle-portal vein. The SP2/0 ascites injected mice were used as controls and the percentage of protection was calculated.Results Active immunization of mice with NP30 could produce protection levels ranging from 22.36% to 50.46% depending on the different immunity protocols. The best immunization protocol was established from the results.Conclusions Active immunization with NP30 can induce a degree of protection to infection with Schistosoma japonicum cercariae and NP30 is a potential vaccine candidate against Schistosoma japonicum.

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