长期经鼻给药对鼻粘膜结构的影响
Influence of intranasal medication on the structure of the nasal mucosa
目的研究长期经鼻吸收药物对鼻粘膜结构的影响及可逆性,为鼻粘膜给药途径长期应用的可行性提供依据.方法使用硫酸庆大霉素给家兔滴鼻,在用药后3,5,7,14,21及28天,并在停药后的同时使用保护鼻粘膜的药物一至三周,取鼻粘膜进行光镜和透射电镜观察.结果用药后3-7天出现渐进性鼻粘膜损伤的改变,二至四周鼻粘膜损伤越来越严重,可出现部分区域上皮的脱落,但基底膜完整.停药后1-3周内上皮细胞及纤毛迅速修复.结论药物对鼻粘膜虽可产生损伤作用,但可以再生修复,鼻内给药途径是有可行性的.
更多Objective To study the influence of intranasal medication on the structure, pathology and reversibility of the nasal mucosa to provide a basis for the feasibility of intranasal route of drug administration. Methods Nasal drops of gentamicin were placed in the nasal cavity of rabbits for 3, 5, 7, 14 and 28 days. After that, the drops were stopped and drugs protecting the nasomucosa were used for one and three weeks. After being sacrificed over time, the nasomucosa of the rabbit was observed under optical and electron microscopes.Results Damage to the nasal mucosa appeared to different extents with prolonged use of nasal drops. Within 3-7 days of applying the drug, damages to the nasal mucosa gradually appeared, and after two and four weeks, were most serious. After stopping the drug, the nasal mucosa was gradually restored.Conclusion Damages of drugs to the nasal mucosa could be restored. The intranasal route of drug administration would be feasible and clinically applicable.
More- 翻译满意度评价:
- 提交
- 浏览:153
- 被引:2
- 下载:52
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文