摘要目的预激综合征为常染色体显性遗传性疾病.但其致病基因尚未定位、克隆.本实验摘要目的是探寻预激综合征的基因位点.方法应用基因分型的方法,以7q3上D7S505,D7S688和 D7S483为候选位点,对3个家族性预激综合征家系(共101名成员)进行了连锁分析.结果家族性预激综合征与上述3个位点均连锁,以D7S505 Lod值最高,重组率(θ)为0.1时Lod=6.4;D7S483和D7S688位点Lod值分别为2.5和5.3.结论预激综合征的相关基因位于7q3上.

abstractsObjective Wolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The Abstract:Objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome.Methods Linkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping.Results Wolff-Parkinson-White syndrome was linked to the loci above.The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (θ) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5. Conclusion The gene of Wolff-Parkinson-White syndrome is located at 7q3.