Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor γ activation up-regulating PTEN and inhibiting PI3K activity

二维码有效期 120s

摘要篇首： As a ligand-dependent transcriptional factor, peroxisome proliferator-activated receptor (PPAR) γ was expressed in several human cancer cells and PPARγ activation could induce cells growth inhibition.1-4 In this study we investigated the PPARγ expression in colon cancer cell line HT-29 and checked the inducement of apoptosis by two PPARγ specific agonists rosiglitazone and 15d-PGJ2. In addition, we also observed the protein expressions of PTEN and p-Akt1 before and after treatment with rosiglitazone and examination whether activation of PPARγ could increase the expression of PTEN in colon cancer cells.

作者单位 Department of Gastroenterology, First Affiliated Hospital, Suzhou Univercity, Suzhou 215006, China ^[1] Institute of Hematology, Suzhou Univercity, Suzhou 215006, China ^[2]

关键词 PPARγ colorectal cancer apoptosis rosiglitazone 15d-PGJ2

分类号 R73

发布时间 2005-11-24

基金项目

the 135 Medical Important Talent Foundation of Jiangsu Province（37RC2002037）

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