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Effect of insulin on the cognizing function and expression of hippocampal Aβ1-40 of rat with Alzheimer disease

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Background A model of simulated Alzheimer's disease (AD) induced by aggregated amyloid protein (Aβ1-40) was built in Wister rats to observe the behavioral and pathological changes of Aβ1-40 and the effect of hypodermic insulin injected on the function of study and memory and the expression of Aβ1-40 from the CA1 area of the hippocampus.Methods Experimental groups were as follows: contrast, simulated AD model, contrast of Nacl, and insulin treated. The simulated AD modet was built by microinjection of aggregated Aβ1-40 at the CA1 area of the hippocampus, and was hypodermically injected with 0.9% NaCI (1 ml/kg) and insulin (0.1 U/kg) separately the next day. Two weeks after the modeling, the four groups were tested with water maze about the study and memory function of rats. Three weeks after the injection, the expression of Aβ1-40 at the CA1 area of the hippocampus was examined by pathological tests (HE,Congo red) and immunohistochemical methods.Results The study and memory abilities of rats were ameliorated significantly by the place navigation test and the spatial probe test after the application of insulin. Insulin could decrease the expression of Aβ1-40 at the CA1 area of the hippocampus to reduce the pathological damage of Aβ1-40 to the hippocampal area of rats.Conclusions The injection of aggregated Aβ1-40 to the hippocampal area could simulate the behavioral and pathological features of AD such as the difficulty of study and memory and the damage to neurons. Insulin is effective to improve the function of study and memory and amend the pathological damage of simulated AD model rats. The results give a experimental proof of insulin in the clinical treatment of AD.

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作者单位: Department of Geriatrics, Second Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China [1]
期刊: 《中华医学杂志(英文版)》2008年121卷9期 827-831页 SCIMEDLINEISTICCSCDBP
分类号: R5
栏目名称: ORIGINAL ARTICLES
发布时间: 2008-06-11
基金项目:
黑龙江省自然科学基金
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