A new variant of the ATP13A2 gene in Chinese patients with early-onset parkinsonism

二维码有效期 120s

摘要篇首： Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by a selective loss of nigrostriatal dopaminergic neurons. Clinical manifestations of this complex disease include resting tremor, bradykinesia, postural instability, gait difficulty and rigidity.

作者单位 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ^[1] Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;Research Center of Neurodegenerative Disorders, Central South University, Changsha, Hunan 410008, China ^[2] National Laboratory of Medical Genetics of China, Changsha,Hunan 410008, China ^[3] Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;National Laboratory of Medical Genetics of China, Changsha,Hunan 410008, China;Research Center of Neurodegenerative Disorders, Central South University, Cha ^[4]

关键词 early-onset parkinsonism ATP13A2 mutation

栏目名称

BRIEF REPORTS

DOI 10.3760/cma.j.issn.0366-6999.2009.24.032

发布时间 2010-03-02

基金项目

grants from the Major State Basic Research Development Program of China (973 Program)（2006cb500700）； the National "863" High-Tech Research and Development Program of China（2006AA02A408）； National Natural Science Foundation of China（30370565,30570638 and 30770735）

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准确一般字义偏差语意偏离译文作用小提交