换一批摘要篇首： The number of individuals affected by chronic obstructive pulmonary disease (COPD) has been increasing in the last decades. As a consequence, COPD is expected to become the third most frequent cause of death worldwide by 2020.1 Exacerbations of COPD is a major cause of morbidity. In particular, they greatly contribute to decline of health-related quality of life,increase in symptoms and breathlessness, Progression of the disease, and increased risk of mortality.2
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