摘要Background The temporal response to off-pump anteroapical aneurysm plication has not been well defined.We have evaluated the long-term clinical and functional results of this technique and compared the efficacy with the patch modeling repair.Methods From March 2005 to May 2010,163 (115 men and 48 women) consecutive patients were operated on for post-infarction left ventricular aneurysm (LVA),54 patients underwent patch remodeling (group A) and 109 patients underwent off-pump anteroapical aneurysm plication repair (group B).All patients had simultaneous coronary revascularization,other operative procedures included septoplasty in eight and ablation of ventricular tachycardia in six.Follow-up ranged from 1 to 5 years,short-term and mid-term outcomes,including complications,cardiac function,and mortality,were assessed.Results Early mortality was 1.8％ for all patients (group A 1 death vs.group B 2 deaths,not significant (NS)).Peri-operative support included intraaortic balloon pumping in 16 (9.8％),(group A 6 patients vs.group B 10 patients,NS)and inotropic drugs in 84 (51.5％),(group A 34 vs.group B 50,NS).During a mean follow-up of (3.7±0.8) years,eight patients died,with four due to cardiac-related causes.No patient required transplantation,and two required use of an implantable cardioverter-defibrillator for ventricular tachycardia.Survival at 1 and 5 years was 95％ and 86％,respectively.It did not differ significantly between group A and group B.Functional class improved from 2.90±0.59 to 1.65±0.54 among the mid-term survivors (P ＜0.001),with no significant difference between the two groups.Pre-operative risk factors for mortality or poor function were ejection fraction (EF) ＜0.35 (OR=7.9,95％ CI 1.6-40.0); congestive heart failure (CHF) (OR=4.4,95％ CI 1.0-19.0); end-systolic volume index (ESVI) ＞80 ml/m2 (OR=3.7,95％ C/ 1.0-14.0); and advanced age ＞70 years (OR=2.4,95％ C/ 1.0-12.0).Conclusions The technique of off-pump anteroapical aneurysm plication associated with coronary grafting can be performed with low operative mortality,providing good symptomatic relief and long-term survival,and similar results can be achieved with patch modeling repair.