摘要Special emphasis about cancer metastasis was concentrated on tumor cells themselves,and we usually considered the ability of migration and invasion was the final decider.Recently,bewaring of tumor microenvironment is a fundamental determinant in metastasis has become the most outstanding breakthrough.Considerable “microbes” in the microenvironment are closely linked with tumor metastatic behaviors,and the major proportion of them is tumor-associated macrophages (TAMs).Actually,TAMs conserve immediate “cross-talk” with cancer cells throughout tumor development.It is generally accepted that TAMs have mostly pro-tumoral functions and play an important role in several stages of tumor progression.This progression involves a series of events that leads from the primary site to the metastatic site,including tumor cell growth,angiogenesis,migration,invasion,intravasation and finally extravasation at distant site where the process begins again (metastasis).Thereby,TAMs has attracted substantial attentions in recent years and could become a promising therapeutic strategy.In this review,we focus on the multi-functions of TAMs in cancer and certain drugs targeting TAMs for cancer treatment those are under experimental research procedures or have even been entered human clinical tests.