Role of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in rheumatic diseases

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摘要Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of structurally related cytokines and is known to induce proliferation,migration,differentiation,apoptotic cell death,inflammation,and angiogenesis.These physiological processes are induced by the binding of TWEAK to fibroblast growth factor-inducible 14 (Fn14),a highly inducible cell-surface receptor that is linked to several intracellular signaling pathways,including the nuclear factor-κB (NF-κB) pathway.This review discusses the role of the TWEAK-Fn14 axis in several rheumatic diseases and the potential therapeutic benefits of modulation of the TWEAK-Fn14 pathway.

作者单位 Department of Rheumatology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China;Department of Rheumatology, Ningde Municipal Hospital, Fujian College of Traditional Chinese Medicine, Ningde, Fujian 352100,China ^[1] Department of Rheumatology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China ^[2]

关键词 tumor necrosis factor-like weak inducer of apoptosis fibroblast growth factor-inducible 14 rheumatic diseases

栏目名称 MEDICAL PROGRESS

DOI 10.3760/cma.j.issn.0366-6999.2012.21.028

发布时间 2013-01-08

基金项目

This study was supported by grants from the National Natural Science Foundation of China the National Natural Science Foundation of Heilongjiang Province "Eleventh Five-Year" National Science and Technology Support Program

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