摘要The malignant glioma is characterized by intrinsic aggressiveness and carries a dismal prognosis.The current standard treatment regimen for patients with malignant gliomas,specifically glioblastoma,is a combined therapy comprised of surgical resection followed by adjunctive radiation and chemotherapy.1 Yet,even with this new multimodality treatment,glioblastoma (GBM) recurs after a median time of 7 months following diagnosis,requiring a second-line treatment.But the clinical decisions are always difficult.Decisions regarding disease management are complicated by the fact that any change in the patient's radiological image suggesting disease progression may be due to radiation-induced injury.
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