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Moxifloxacin-induced multiple organ dysfunction possibly related to mutations in several genes involved in drug metabolism pathways

摘要Quinolones have been used to treat various infectious diseases.The addition of fluorine atoms has allowed for extensive modifications of structures,which has enhanced the spectrum of activities and oral bioavailability of quinolones and resulted in the creation of fluoroquinolones.1 Although the adverse effects associated with fluoroquinolone antibiotics have decreased considerably and these drugs are generally well tolerated,adverse effects do sometimes occur.Previous studies have shown that the most common side effects are nausea and diarrhea (>5%),dizziness (2.5%-3.6%),skin lesions (<2.5%),central nervous system disorders (1%-2%),and liver function test abnormalities (1.1%).2,3We herein report a patient who suffered from multiple organ dysfunction (MOD) after intravenous infusion of moxifloxacin.

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作者单位 Department of Respiratory Medicine, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China ;Department of Respiratory Medicine, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese People's Liberation Army, Lanzhou, Gansu 730050, China [1] Department of Respiratory Medicine, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China;Medical College of Nankai University, Tianjin 300071, China [2] Department of Respiratory Medicine, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China [3] Department of Respiratory Medicine, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China;Department of Respiratory Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China [4]
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DOI 10.3760/cma.j.issn.0366-6999.20121691
发布时间 2013-06-05(万方平台首次上网日期,不代表论文的发表时间)
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中华医学杂志(英文版)

中华医学杂志(英文版)

2013年7期

1396-1398页

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