换一批
换一批Beyond retinocytomas: clinical benefit of topotecan in the management of other intra-cranial tumors especially glioblastomas
摘要To the editor:Zhang et all have provided interesting data in their recent article.Topotecan may of clinical benefit in the management of other intra-cranial tumors especially glioblastomas.For instance,topotecan has a negative effect on intra-tumoral angiogenesis in glioblastomas.Hypoxia-inducible factor-1 (HIF-1)target genes are significantly inhibited at the same time thus further attenuating tumor growth.2 Addition of topotecan also is of additional clinical benefit when used in conjunction with radiotherapy in the management of glioblastomas.The six months progression free survival is augmented by almost 16％.Similarly the two year overall survival rates are augmented by 6％.
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栏目名称
LETTERS
DOI
10.3760/cma.j.issn.0366-6999.20130335
发布时间
2013-08-05
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