摘要Background Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy.Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment.Methods In this study,the inhibitory effects of c-Met phosphorylation were observed with SU11274 on different colon cancer cell lines in vitro.Results The results revealed the significant inhibitory effects of SU 11274 on cell proliferation and cell survival,in a time and dose-dependent manner.Furthermore,the inhibitory effects of SU11274 on different subgroups of colon cancer cells via the HGF/c-Met signaling pathway were implicated in this study.Conclusion The results suggested the possible selective therapeutic effects of c-Met inhibitor on colon cancer.