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Uncoupling protein and nonalcoholic fatty liver disease

摘要Objective To review the current advances on the role of uncoupling protein (UCP) in the pathogenesis and progress of nonalcoholic fatty liver disease (NAFLD).Data sources A comprehensive search of the PubMed literature without restriction on the publication date was carried out using keywords such as UCP and NAFLD.Study selection Articles containing information related to NAFLD and UCP were selected and carefully analyzed.Results The typical concepts,up-to-date findings,and existing controversies of UCP2 in NAFLD were summarized.Besides,the effect of a novel subtype of UCP (hepatocellular down regulated mitochondrial carrier protein,HDMCP) in NAFLD was also analyzed.Finally,the concept that any mitochondrial inner membrane carrier protein may have,more or less,the uncoupling ability was reinforced.Conclusions Considering the importance of NAFLD in clinics and UCP in energy metabolism,we believe that this review may raise research enthusiasm on the effect of UCP in NAFLD and provide a novel mechanism and therapeutic target for NAFLD.

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作者单位 Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou,Zhejiang 310003, China [1] Department of Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou,Zhejiang 310003, China [2] Department of Gastroenterology, The Affiliated Hospital, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310003, China [3]
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DOI 10.3760/cma.j.issn.0366-6999.20130940
发布时间 2013-09-27
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中华医学杂志(英文版)

中华医学杂志(英文版)

2013年126卷16期

3151-3155页

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