Podocyte-related proteins in membranous nephropathy progression

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摘要Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults.The renal biopsy is the gold standard for the disease diagnosis,but is invasive.M-type phospholipase A2 receptor (PLA2R) on human podocytes could serve as the target for podocytopathic antibodies (anti-PLA2R).1 Patients with iMN (70％-80％) were found the circulating antibodies against PLA2R.1 And the podocyte-secreted angiopoietinlike-4 (Angptl4) could be another key role in nephrotic syndrome3.

作者单位 Kidney Disease Center, the First Affiliated Hospital, Zhejiang University College of Medicine; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine of China; Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China; Key Laboratory of Nephropathy, Zhejiang Province, Hangzhou, Zhejiang 310003, China ^[1]

关键词 PLA2R Angptl4 membranous nephropathy podocyte

栏目名称

SHORT COMMUNICATION

DOI 10.3760/cma.j.issn.0366-6999.20131056

发布时间 2013-11-12

基金项目

This study was supported by the grants from the National Nature Science Foundation of China （2011BAI10B07,2012CB517603,and 2012AA02A512）

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准确一般字义偏差语意偏离译文作用小提交