摘要Background C-reactive protein (CRP) gene +1059 G/C polymorphism has been reported to be associated with coronary heart disease (CHD) risk,but the results remain inconclusive.This meta-analysis was therefore conducted to clarify these controversies.Methods A comprehensive search was conducted to identify all case control studies on the association between CRP gene +1059 G/C polymorphism and CHD risk.All the related studies were further strictly selected according to the inclusion criteria.Meta-analysis was performed with STATA 10.1 (StataCorp,USA).The association was assessed by odds ratio (OR) and 95％ confidence interval (CI); both Begg's funnel plot and Egger's regression test were used to assess the publication bias.Results This meta-analysis on a total of 13 studies comprising 6316 CHD cases and 4467 controls showed no significant association between CRP gene +1059 G/C polymorphism and CHD risk in the overall study (for C/C+C/G vs.G/G:OR=1.01,95％ CI=0.81-1.25,P=0.96; for C/C vs.C/G+G/G:OR=1.17,95％ CI=0.77-1.77,P=0.47; for C/C vs.G/G:OR=1.17,95％ CI=0.77-1.77,P=0.47; for C allele vs.G allele:OR=1.01,95％ CI=0.81-1.24,P=0.96).However,in the subgroup analysis by ethnicity,the results showed significant association between CRP gene +1059 G/C polymorphism and CHD risk among Caucasians (for C/C vs.G/G:OR=2.54,95％ CI=1.13-5.72,P=0.02; C/C vs.C/G+G/G:OR=2.45,95％ CI=1.09-5.51,P=0.03),but not among Asians and Africans (P ＞0.05).Conclusion CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.