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Comparison of proliferation index between nestin-positive cells and glial fibrillary acidic protein-positive cells in human astrocytic tumors

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摘要Multivariate modeling has demonstrated that the proliferation index (PI) of tumor cells is one of the str ongest prognostic factors related to the survival of patients with astrocytic tumors.Studies have indicated that the glioma regenerative cells derived from nestin-positive (N+) cells after chemotherapy.Early removal of N+ cells can block the malignant progress of tumor.2 However,few studies compared the PI between N+ cells and glial fibrillary acidic protein (GFAP)-positive (GFAP+) cells in human astrocytic tumors.In the present study,we investigated the distribution and proliferation ofN+ cells and GFAP+ cells in human astrocytic tumors to clarify the role these cells play in the cytopathology of these tumors.

作者单位 Department of Pharmacology, Fujian Medical University, Fuzhou,Fujian 350005, China ^[1] Department of Pathology ,First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China ^[2] Department of Neurosurgery ,First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China ^[3]

关键词 glioma nestin glial fibrillary acidic protein proliferation index

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DOI 10.3760/cma.j.issn.0366-6999.20132526

发布时间 2014-03-06（万方平台首次上网日期，不代表论文的发表时间）

基金项目

This study was supported by grants from the National Natural Science Foundation of China（30973083）； the Science and Technology Commission,Fujian,China（2007I0014）； Science Research Foundation of Ministry of Health & United Fujian Provincial Health and Education Project for Tackling the Key Research（WKJ2008-2-45）

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