摘要Optic neuritis (ON),an acute inflammatory optic neuropathy,causes conduction blocks in the optic nerve and a series of visual functional changes.It is characterized not only by the inflammation of the optic nerve but also the visual dysfunction caused by the neuropathy involving optic chiasm,lateral geniculate body,optic radiation,and visual cortex.Clinical diagnosis mainly relies on the visual function evaluation using electrophysiology,vision examination,and magnetic resonance imaging (MRI).However,pattern-visual evoked potential (P-VEP) and visual field examination have limitation.Blood-oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI),an integrative modality of the function,images and anatomy,can be used to monitor the status of brain activity in the functional areas in vivo.The present study aimed to examine the status of functional activities of the visual cortex in the patients with optic neuritis using of BOLD-fMRI technique and to evaluate the application of fMRI in the optic neuritis.