摘要Nephrolithiasis is a common source of morbidity with a lifetime prevalence of 5 ％-10％.Despite technical advances in the treatment of nephrolithiasis,the prevalence of stone disease appears to be increasing.Raised serum and/or urinary uric acid are a well-established risk factor for calculogenesis.Hyperuricemia is a level of uric acid in the blood that is abnormally high.Urinary stones are often found in patients with hyperuricemia.This excess uric acid may lead to the formation of uric acid-related nephrolithiasis.Uric acid-related nephrolithiasis may involve calcium stones,uric acid stones,or a combination of both.In some cases,uric acid crystals act as nucleus and calcium oxalate crystals get deposited around the uric acid nucleus due to epitaxy and lead to uric acid-induced calcium oxalate stones.