摘要Backgorund Sleep deprivation (SD) has been used in treatment of depression disorder,and could effectively improve the patients' depressive symptoms.The aim of the study was to explore the effects of SD on electroencephalographic (EEG)and executive function changes in patients with depression.Methods Eighteen depression patients (DPs) and 21 healthy controls (HCs) were enrolled in the present study.The whole night polysomnography (PSG) was recorded by Neurofax-1518K (Nihon Kohden,Japan) system before and after 36 hours of SD.The level of subjects' depression state was assessed by Visual Analogue Scale (VAS),and the executive function was assessed by Wisconsin Card Sorting Test (WCST).Results Significantly decreased sleep latency (SL; before SD:(31.8±11.1) minutes,after SD:(8.8±5.2) minutes,P ＜0.01)and REM sleep latency (RL; before SD:(79.8±13.5) minutes,after SD:(62.9±10.2) minutes,P ＜0.01) were found after SD PSG in depression patients.Decreased Stage 1 (S1; before SD:(11.7±2.9)％,after SD:(7.3±1.1)％,P ＜0.01) and Stage 2(S2,before SD:(53.8±15.5)％,after SD:(42.3±14.7)％,P ＜0.05) of non-rapid eye movement (NREM) sleep,and increased Stage 3 (S3,before SD:(11.8±5.5)％,after SD:(23.6±5.8)％,P＜0.01) and Stage 4 (S4,before SD:(8.8±3.3)％,after SD:(27.4±4.8)％,P ＜0.01) NREM sleep were also found.After SD,the depression level in patients decreased from 6.7±2.1to 2.9±0.7 (P ＜0.01).In WCST,the patients showed significantly decreased Response errors (Re,before SD:22.3±2.4,after SD:18.3±2.7,P ＜0.01) and Response preservative errors (Rpe,before SD:11.6±3.6,after SD:9.3±2.9,P＜0.05).Depression patients' RE (t=2.17,P ＜0.05) and Rpe (t=2.96,P ＜0.01) also decreased significantly compared to healthy controls.Conclusion SD can improve depression symptom and executive function in depression patients.