摘要As a guest editor for this special issue of Neurology Diseases in the Chinese Medical Journal (English Edition),I am pleased to announce a completion of 19 articles (13 research articles,4 review papers and 2 case reports) which cover a spectrum of research frontier in neurology diseases for publication in this issue.These articles provide an update on the state of clinical and basic science research in movement disorders (Huntington disease,Parkinson's disease,spinocerebellar ataxias (SCAs),and Wilson's disease),amyotrophic lateral sclerosis,cerebral vascular disease,epilepsy,infection/immunology diseases,and rare genetic disorders (mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes [MELAS] and facioscapulohumeral muscular dystrophy [FSHD]).While substantial progress in our understanding of these disorders has been achieved,development of accurate diagnosis procedures and precise treatments remains an unrealized goal.