Successful Treatment with Rituximab in a Patient with Castleman's Disease Complicated by Systemic Lupus Erythematosus and Severe Autoimmune Thrombocytopenia
摘要To the Editor:A 44-year-old man with no remarkable past medical history,was admitted with 1-month history of fever and lymphadenopathy.He also had night sweats,malaise,arthralgia,urine volume reduction,abdominal distention,and weight loss.Physical examination revealed swollen lymph nodes in the neck,axillary fossae and inguinal grooves,palpable liver and spleen,shifting dullness and edema.Laboratory investigation showed anemia (hemoglobin 89 g/L) and severe thrombocytopenia (platelet 9 × 109/L),positive urine red blood cell and urine protein (0.68 g/24 h),elevated creatinine (180 μmol/L),elevated erythrocyte sedimentation rate (ESR) (35 mm/h),elevated gammaglobulins (IgG 19.3 g/L),and low albumin level (27 g/L).Antinuclear antibody (ANA,speckled pattern,1:160),anti-dsDNA,and anti-SSA antibodies were positive.
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