摘要Objective:Postural tachycardia syndrome (POTS) is one of the major causes of orthostatic intolerance in children.We systematically reviewed the pathogenesis and the progress of individualized treatment for POTS in children.Data Sources:The data analyzed in this review are mainly from articles included in PubMed and EMBASE.Study Selection:The original articles and critical reviews about POTS were selected for this review.Results:Studies have shown that POTS might be related to several factors including hypovolemia,high catecholamine status,abnormal local vascular tension,and decreased skeletal muscle pump activity.In addition to exercise training,the first-line treatments mainly include oral rehydration salts,beta-adrenoreceptor blockers,and alpha-adrenoreceptor agonists.However,reports about the effectiveness of various treatments are diverse.By analyzing the patient's physiological indexes and biomarkers before the treatment,the efficacy of medication could be well predicted.Conclusions:The pathogenesis of POTS is multifactorial,including hypovolemia,abnormal catecholamine state,and vascular dysfunction.Biomarker-directed individualized treatment is an important strategy for the management of POTS children.