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Comparison of Composition and Diversity of Bacterial Microbiome in Human Upper and Lower Respiratory Tract

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摘要INTRODUCTION Microbiome residing in the airways and parenchymal tissues,as a biological barrier of respiratory tract,plays an important role in maintaining the normal functions of individual's respiratory system and preventing the invasion and colonization of exogenous pathogens.[1] Changes of microbial community may result in the occurrence and progression of infectious pneumonia and acute exacerbation of chronic diseases,through disordering commensal microorganisms and increasing invasive ability of pathogens.

作者单位 Department of Respiratory Medicine, Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, China ^[1] Department of Immunology and The Research Centre of Microbiome, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China ^[2] Department of Respiratory Disease, Capital Medical University, Beijing 100069, China;China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing 100029, China ^[3]

关键词 16S rRNA Gene Sequencing Bronchoalveolar Lavage Fluid Microbiota Respiratory Tract Sputum

栏目名称

Clinical Experience

DOI 10.4103/0366-6999.204934

发布时间 2017-06-05（万方平台首次上网日期，不代表论文的发表时间）

基金项目

This study was supported by the grants from the National Natural Science Foundation of China（81373177,and 81471594）； the Key Projects in the National Science and Technology pillar program（2013BAI09B10）； the Basic-clinical Research Cooperation Issues of Capital Medical University（17JL90）

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